Neuropsychiatric features in Alzheimer's disease

 
   Lead Investigator:    Michael Cuccaro
   Institution      :    University of Miami Miller School of Medicine
   E-Mail           :    mcuccaro@med.miami.edu
   Proposal ID      :    1495



   Proposal Description:
   Neuropsychiatric (NP) features are a common co-occurrence among individuals  with Alzheimer's disease related disorders (ADRD). The relationship between NP   features and clinical outcomes in ADRD is not well understood. The objectives     of this project are to understand  the occurrence of NP features across           different population groups and their relationship to ADRD outcomes. To           accomplish these objectives we propose the following  aims:                       SA1. Establish the prevalence of NP features across different population         groups.                                                                           SA2. Analyze the association of NP features within population groups to           multiple variables including age, education, cognition, severity, and vascular   risk factors                                                                     SA3 Analyze the association of NP features to APOE and select biomarkers.         The results of this study will expand our understanding of the relationship of   NP features to ADRD outcomes. We believe that the complex biology of NP feature  impact ADRD outcomes and this study is a first step in disentangling their       role.